{"product_id":"skin-hair-analysis-products-c-k-scientific-products-probes-tewitro-tw-24-transepidermal-waterloss-measurement-in-skin-tissue-models","title":"Tewitro TW 24 Transepidermal Waterloss Measurement in Skin Tissue Models","description":"\u003ch2 class=\"uk-margin-remove-top uk-h3\"\u003eTransepidermal Waterloss Measurement in Skin Tissue Models\u003c\/h2\u003e\r\n\u003cdiv class=\"uk-margin\"\u003e\r\n\u003cp\u003eThe Tewitro\u003cspan\u003e®\u003c\/span\u003e TW 24 is the \u003cspan\u003eonly device\u003c\/span\u003e to measure the \u003cspan\u003ewater evaporation from cultured tissue sets\u003c\/span\u003e (wells in a plate with medium) in \u003cspan\u003eup to 24 wells simultaneously\u003c\/span\u003e with the worldwide most used “open chamber” measurement of the Tewameter\u003cspan\u003e®\u003c\/span\u003e.\u003c\/p\u003e\r\n\u003cp\u003e \u003c\/p\u003e\r\n\u003cdiv class=\"uk-margin-small\"\u003e\r\n\u003cdiv class=\"uk-child-width-expand uk-grid\"\u003e\n\u003cspan style=\"font-size: 11.7px;\"\u003e\u003cstrong\u003e\u003cbr\u003e\u003c\/strong\u003e\u003c\/span\u003e\r\n\u003ch3 class=\"el-title uk-margin\" style=\"display: inline !important;\"\u003eFields of Application\u003c\/h3\u003e\r\n\u003cdiv class=\"el-content uk-margin\"\u003e\r\n\u003cp\u003eFor each product to be applied to the skin, safetymeasurements are indispensable. The use of skin tissue models for long-term safety tests is a quick and easy method to avoid using animals or volunteers.\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003eIt is the only way to study skin permeability and dermal absorption necessary for safety and efficacy testing\u003c\/li\u003e\r\n\u003cli\u003eIn vitro tests and procedures to minimize the use of animals in tests are established in several worldwide acknowledged guidelines: e.g. \u003ca href=\"https:\/\/ec.europa.eu\/jrc\/en\/eurl\/ecvam\" rel=\"noopener\" target=\"_blank\"\u003eECVAM\u003c\/a\u003e (European Centre for the Validation of Alternatives to Animal Testing), \u003ca href=\"https:\/\/www.oecd.org\/publications\/test-no-439-in-vitro-skin-irritation-9789264090958-en.htm\" rel=\"noopener\" target=\"_blank\"\u003eOECD \u003c\/a\u003e(Organisation for Economic Co-operation and Development) or \u003ca href=\"https:\/\/echa.europa.eu\/animal-testing-under-reach\" rel=\"noopener\" target=\"_blank\"\u003eREACH\u003c\/a\u003e (Registration, Evaluation, Authorisation and Restriction of Chemicals)\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp\u003eWhenever the barrier is damaged, the evaporation rate will increase immediately. Also for claims related to barrier improvement\/enhancing, tests on cultured cells are needed, as products meant to keep the barrier intact or to even improve it, can be detected by a stable Transepidermal Water Loss (TEWL).\u003cbr\u003e\u003cbr\u003e\u003cspan class=\"fontstyle0\"\u003eThe Tewitro® \u003c\/span\u003e\u003cspan class=\"fontstyle2\"\u003eis well-suited to non-invasively monitor TEWL of cultured skin tissue samples\u003c\/span\u003e\u003cspan class=\"fontstyle2\"\u003e. These results open up new opportunities to monitor the dermal barrier physiology under different experimental conditions and treatments \u003c\/span\u003e\u003cspan class=\"fontstyle3\"\u003ein vitro\u003c\/span\u003e\u003cspan class=\"fontstyle2\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp\u003e \u003c\/p\u003e\r\n\u003cp\u003e \u003c\/p\u003e\r\n\u003ch3 class=\"el-title uk-margin\"\u003eTewitro® Measurement Principle\u003c\/h3\u003e\r\n\u003cdiv class=\"el-content uk-margin\"\u003e\r\n\u003cp\u003e\u003ca title=\"unique - the Tewitro®\" href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0704\/1427\/0699\/files\/Tewitro01.jpg?v=1723220444\" rel=\"noopener\" target=\"_blank\" data-wk-lightbox=\"on\" data-uk-lightbox=\"on\"\u003e\u003cimg title=\"unique - the Tewitro®\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0704\/1427\/0699\/files\/Tewitro01.jpg?v=1723220444\" alt=\"Tewitro01\" width=\"247\" height=\"234\"\u003e\u003c\/a\u003e          \u003ca title='\"open champer\" TEWL detection per inlet' href=\"https:\/\/www.courage-khazaka.de\/images\/Produkte\/wissenschaftliche-Produkte\/Tewitro\/Tewitro-inlet-d.jpg\" target=\"_blank\" data-wk-lightbox=\"on\" data-uk-lightbox=\"on\"\u003e\u003cimg title='\"open champer\" TEWL detection per inlet' src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0704\/1427\/0699\/files\/Tewitro-inlet-e.jpg?v=1723220449\" alt=\"Tewitro inlet e\" width=\"280\" height=\"230\"\u003e\u003c\/a\u003e\u003c\/p\u003e\r\n\u003cp\u003eFully equipped, the Tewitro\u003cspan\u003e®\u003c\/span\u003e TW 24 can be used in standard \u003cspan\u003e24-wells plates (6x4)\u003c\/span\u003e. The probe features 6 slots with 4 measurement inlets each, but is also available as \u003cspan\u003esingle rows\u003c\/span\u003e of 1 slot with 4 measuring inlets (respectively for 8, 12, 16 or 20 inlets), depending on the used well plate size. Each measurement inlet features\u003cspan\u003e two sensor pairs constantly measuring temperature and relative humidity\u003c\/span\u003e, thus measuring in an indirect way the density gradient of the water evaporation from the surface of the bottom of the well. This gradient equals the \u003cspan\u003eTransepidermal Water Loss\u003c\/span\u003e typically measured on the in vivo skin surface in \u003cspan\u003eg\/h\/m²\u003c\/span\u003e. This \"open chamber\" TEWL measurement method is the worldwide most-used method to quantify the barrier function of the skin. \u003ca href=\"https:\/\/www.courage-khazaka.de\/images\/Downloads\/Studien\/Studies_Tewameter.pdf\" target=\"_blank\"\u003eHundreds of publications\u003c\/a\u003e prove this fact. The Tewameter\u003cspan\u003e®\u003c\/span\u003e had even been used on board of the International Space Station (ISS) to monitor the astronaut's skin during long-term exposure in space.\u003c\/p\u003e\r\n\u003c\/div\u003e\r\n\u003cp\u003e \u003c\/p\u003e\r\n\u003ch3 class=\"el-title uk-margin\"\u003eSoftware\u003c\/h3\u003e\r\n\u003cdiv class=\"el-content uk-margin\"\u003e\r\n\u003cul\u003e\r\n\u003cli\u003eThe \u003cspan\u003econvenient\u003c\/span\u003e and \u003cspan\u003eorganized\u003c\/span\u003e software offers \u003cspan\u003e24 TEWL-values\u003c\/span\u003e (one for each measurement inlet), with two different adjustable \u003cspan\u003eaverages and their respective standard deviations\u003c\/span\u003e as well as the possibility of displaying and saving the \u003cspan\u003eRH and temperature value for the upper and lower sensor pair for each measurement inlet\u003c\/span\u003e (2 x 24) separately.\u003c\/li\u003e\r\n\u003cli\u003e\n\u003cspan\u003eGraphical view\u003c\/span\u003e for each measurement inlet with one click\u003c\/li\u003e\r\n\u003cli\u003eMeasurements from a \u003cspan\u003ecouple of seconds\u003c\/span\u003e up to \u003cspan\u003e24 h long-term\u003c\/span\u003e studies are possible.\u003c\/li\u003e\r\n\u003cli\u003e\n\u003cspan\u003eAutomatic stop conditions\u003c\/span\u003e for the measurement (stability of the measurement or time)\u003c\/li\u003e\r\n\u003cli\u003eWarning displayed, if RH exceeds the range for regular measurement uncertainty.\u003c\/li\u003e\r\n\u003cli\u003e\n\u003cspan\u003eEasy\u003c\/span\u003e \u0026amp; \u003cspan\u003equick check calibration\u003c\/span\u003e and offset\u003c\/li\u003e\r\n\u003cli\u003eIf the \u003cspan\u003eAmbient Condition Sensor probe\u003c\/span\u003e is connected, its values are constantly recorded during the measurement and saved with the results.\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp\u003e \u003c\/p\u003e\r\n\u003cp\u003e\u003cimg title=\"extremely convenient software of the Tewitro®\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0704\/1427\/0699\/files\/Tewitro-software-close-up.jpg?v=1723220454\" alt=\"Tewitro software close up\" width=\"205\" height=\"184\"\u003e\u003c\/p\u003e\r\n\u003cdiv id=\"wk-grid3ce\" class=\"wk-grid-width-1-1 wk-grid-width-small-1-2 wk-grid-width-large-1-2 wk-grid wk-grid-match \" data-wk-grid-match=\"{target:'\u0026gt; div \u0026gt; .wk-panel', row:true}\" data-wk-grid-margin=\"\"\u003e\r\n\u003cdiv class=\"wk-row-first\"\u003e\r\n\u003cdiv class=\"wk-panel\"\u003e \u003c\/div\u003e\r\n\u003cdiv class=\"wk-panel\"\u003e\n\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0704\/1427\/0699\/files\/Tewitro-table-view.jpg?v=1723220461\" alt=\"Tewitro® - convenient table of all measurements\" width=\"387\" height=\"210\"\u003e        \u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0704\/1427\/0699\/files\/Tewitro-curve-view.jpg?v=1723220466\" alt=\"Curves in detail for all measurements\" width=\"394\" height=\"212\"\u003e\r\n\u003cdiv class=\"wk-overlay-panel wk-overlay-fade wk-flex wk-flex-center wk-flex-middle wk-text-center\"\u003e \u003c\/div\u003e\r\n\u003c\/div\u003e\r\n\u003c\/div\u003e\r\n\u003cdiv class=\"wk-row-first\"\u003e\r\n\u003cdiv class=\"wk-panel\"\u003e\r\n\u003cdiv class=\"wk-overlay-panel wk-overlay-fade wk-flex wk-flex-center wk-flex-middle wk-text-center\"\u003e \u003c\/div\u003e\r\n\u003c\/div\u003e\r\n\u003c\/div\u003e\r\n\u003c\/div\u003e\r\n\u003c\/div\u003e\r\n\u003ch3 class=\"el-title uk-margin\"\u003eUse on In Vitro Tissue Models\u003c\/h3\u003e\r\n\u003cdiv class=\"el-content uk-margin\"\u003e\r\n\u003cp\u003eThe Tewitro\u003cspan\u003e®\u003c\/span\u003e TW 24 can measure in the \u003cspan\u003ewell plates of cultured tissue\u003c\/span\u003e. Until now, we have experience with the following \u003cspan\u003ereadily on the market available models\u003c\/span\u003e:\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\n\u003cspan\u003eLab cyte\u003c\/span\u003e (\u003ca href=\"https:\/\/www.labcyte.com\/\" rel=\"noopener\" target=\"_blank\"\u003ewww.labcyte.com\u003c\/a\u003e), \u003cspan\u003eEPI-MODEL\u003cspan\u003e®\u003c\/span\u003e 24\u003c\/span\u003e, a product of the Corning \"Falcon\" series and\u003c\/li\u003e\r\n\u003cli\u003e\n\u003cspan\u003eEpiskin\u003cspan\u003e®\u003c\/span\u003e\u003c\/span\u003e products Skin Ethic\u003cspan\u003e®\u003c\/span\u003e RHE and RHPE \u003c\/li\u003e\r\n\u003cli\u003e8 mm, 0.5 cm\u003cspan\u003e2\u003c\/span\u003e (\u003ca href=\"https:\/\/www.episkin.com\/SkinEthic-RHE\" rel=\"noopener\" target=\"_blank\"\u003ewww.episkin.com\/en\/SkinEthic-RHE\u003c\/a\u003e) – with additional adapters\u003c\/li\u003e\r\n\u003cli\u003eMattek \u003cspan\u003eEpiderm\u003cspan\u003e®\u003c\/span\u003e \u003c\/span\u003e24 wells set (\u003ca href=\"https:\/\/www.mattek.com\/\" rel=\"noopener\" target=\"_blank\"\u003ewww.mattek.com)\u003c\/a\u003e – with additional adapters\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp\u003e \u003c\/p\u003e\r\n\u003cp\u003e\u003cimg title=\"adapter for Episkin® and Epiderm® products\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0704\/1427\/0699\/files\/Tewitro-adapter.jpg?v=1723220472\" alt=\"Tewitro adapter\" width=\"200\" height=\"179\"\u003e\u003c\/p\u003e\r\n\u003cp\u003e \u003c\/p\u003e\r\n\u003cp\u003e\u003cspan\u003e\u003cbr\u003eTewitro\u003cspan\u003e®\u003c\/span\u003e TW 24R\u003cbr\u003e\u003c\/span\u003eThe Tewitro\u003cspan\u003e®\u003c\/span\u003e TW 24R has been developed to allow TEWL measurements on full thickness reconstructed epidermis. This probe has slightly higher feet and is delivered with stainless steel diffusion tubes.\u003cbr\u003e\u003cspan\u003eExample:\u003cbr\u003e\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003e\u003ca href=\"https:\/\/www.phenion.com\/\" rel=\"noopener\" target=\"_blank\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0704\/1427\/0699\/files\/Phenion_20Logo.jpg?v=1723220477\" alt=\"Phenion Logo\" width=\"100\" height=\"39\"\u003e\u003c\/a\u003ePhenion\u003cspan\u003e®\u003c\/span\u003e FT \u003c\/span\u003e(\u003ca href=\"https:\/\/www.phenion.com\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.phenion.com\u003c\/a\u003e) \u003cspan\u003eby Henkel\u003c\/span\u003e directly in the wells.\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\r\n\u003cp\u003e \u003c\/p\u003e\r\n\u003cdiv id=\"wk-grid8e3\" class=\"wk-grid-width-1-1 wk-grid-width-small-1-2 wk-grid-width-large-1-4 wk-grid wk-grid-match \" data-wk-grid-match=\"{target:'\u0026gt; div \u0026gt; .wk-panel', row:true}\" data-wk-grid-margin=\"\"\u003e\r\n\u003cdiv class=\"wk-row-first\"\u003e\r\n\u003cdiv class=\"wk-panel\"\u003e\n\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0704\/1427\/0699\/files\/TWR-full-thickness-models1.jpg?v=1723220484\" alt=\"Tewitro® TW 24R - measurements on full thickness skin models\" width=\"311\" height=\"207\"\u003e                         \u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0704\/1427\/0699\/files\/TWR-putting-on.jpg?v=1723220490\" alt=\"Putting on the Tewitro® TW 24R\" width=\"308\" height=\"205\"\u003e\r\n\u003cdiv class=\"wk-overlay-panel wk-overlay-fade wk-flex wk-flex-center wk-flex-middle wk-text-center\"\u003e \u003c\/div\u003e\r\n\u003c\/div\u003e\r\n\u003c\/div\u003e\r\n\u003cdiv class=\"wk-row-first\"\u003e\r\n\u003cdiv class=\"wk-panel\"\u003e\r\n\u003cdiv class=\"wk-overlay-panel wk-overlay-fade wk-flex wk-flex-center wk-flex-middle wk-text-center\"\u003e \u003c\/div\u003e\r\n\u003c\/div\u003e\r\n\u003c\/div\u003e\r\n\u003cdiv class=\"wk-row-first\"\u003e\r\n\u003cdiv class=\"wk-panel\"\u003e\r\n\u003cdiv class=\"wk-overlay-panel wk-overlay-fade wk-flex wk-flex-center wk-flex-middle wk-text-center\"\u003e \u003c\/div\u003e\r\n\u003c\/div\u003e\r\n\u003c\/div\u003e\r\n\u003cdiv class=\"wk-row-first\"\u003e\r\n\u003cdiv class=\"wk-panel\"\u003e\n\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0704\/1427\/0699\/files\/TWR-lifting-tubes.jpg?v=1723220496\" alt=\"Tewitro® TW 24R - stainless steel diffusion channels\" width=\"344\" height=\"229\"\u003e                \u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0704\/1427\/0699\/files\/TWR-ready.jpg?v=1723220501\" alt=\"Tewitro® TW 24R - ready to measure\" width=\"344\" height=\"229\"\u003e\r\n\u003cdiv class=\"wk-overlay-panel wk-overlay-fade wk-flex wk-flex-center wk-flex-middle wk-text-center\"\u003e \u003c\/div\u003e\r\n\u003c\/div\u003e\r\n\u003c\/div\u003e\r\n\u003c\/div\u003e\r\n\u003cbr\u003eFor \u003cspan\u003eother models, please check with us\u003c\/span\u003e by providing a sample. The\u003cspan\u003e probe can be custom fitted to many different systems\u003c\/span\u003e (ask for a price offer).\r\n\u003cp\u003e \u003c\/p\u003e\r\n\u003cp\u003eFor the measurement of TEWL, the plate with the wells and the measurement probe has to be \u003cspan\u003eheated to skin temperature\u003c\/span\u003e. The laboratory condition is rather cool (20-22°C), in this condition differences in TEWL are barely visible. As soon as the system is heated to skin temperature, the differences become immediately obvious. \u003cspan\u003eWe recommend to use a heating plate\u003c\/span\u003e with a temperature around 33 °C.\u003c\/p\u003e\r\n\u003c\/div\u003e\r\n\u003cp\u003e \u003c\/p\u003e\r\n\u003ch3 class=\"el-title uk-margin\"\u003eTypical Application Examples\u003c\/h3\u003e\r\n\u003cdiv class=\"el-content uk-margin\"\u003e\r\n\u003cp\u003e\u003cspan\u003eOn pre-cultured tissue before the product(s) to be tested are applied:\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp\u003e\u003ca title=\"Determine the perfect time for product application\" href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0704\/1427\/0699\/files\/Tewitro-product-appl.jpg?v=1723220505\" target=\"_blank\" data-wk-lightbox=\"on\" data-uk-lightbox=\"on\"\u003e\u003cimg title=\"Determine the perfect time for product application\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0704\/1427\/0699\/files\/Tewitro-product-appl.jpg?v=1723220505\" alt=\"Tewitro product appl\" width=\"228\" height=\"152\"\u003e\u003c\/a\u003e\u003c\/p\u003e\r\n\u003cp\u003e\u003cspan\u003eConstant measurement of the evaporating water\u003c\/span\u003e which is typical for the wells when coming out of the incubator until a normal TEWL value (for incubated cell cultures) is reached. When the probe starts to measure, the TEWL is very high but constantly decreasing. As soon as it has reached a stable plateau, it indicates that the \u003cspan\u003etissue cultures are now ready for the application of the product\u003c\/span\u003e. At the same time, the recorded TEWL is a control value (before application).\u003c\/p\u003e\r\n\u003cspan\u003eBenefits:\u003cbr\u003e\u003c\/span\u003e\r\n\u003cul\u003e\r\n\u003cli\u003eThe probe can \u003cspan\u003econstantly measure over longer periods\u003c\/span\u003e (only possible with open chamber measurements).\u003c\/li\u003e\r\n\u003cli\u003eThe measurement shows that all tissue cultures are ok (\u003cspan\u003equality check\u003c\/span\u003e).\u003c\/li\u003e\r\n\u003cli\u003eThe software can indicate that the TEWL has reached a \u003cspan\u003estable threshold value\u003c\/span\u003e.\u003c\/li\u003e\r\n\u003cli\u003eYou can be sure to \u003cspan\u003eapply the tested products in repeated tests\u003c\/span\u003e to tissue cultures \u003cspan\u003eunder the same conditions\u003c\/span\u003e.\u003c\/li\u003e\r\n\u003cli\u003e\n\u003cspan\u003eControl value\u003c\/span\u003e of all wells used is recorded \u003cspan\u003ebefore application\u003c\/span\u003e, so that the later measured effects can be surely attributed to the product.\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp\u003e\u003cspan\u003eMeasuring the actual effect on the barrier function of applied products (safety \u0026amp; efficacy):\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp\u003e\u003ca title=\"measuring TEWL on all 24 wells at the same time\" href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0704\/1427\/0699\/files\/Tewitro-MPA.jpg?v=1723220512\" target=\"_blank\" data-wk-lightbox=\"on\" data-uk-lightbox=\"on\"\u003e\u003cimg title=\"measuring TEWL on all 24 wells at the same time\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0704\/1427\/0699\/files\/Tewitro-MPA.jpg?v=1723220512\" alt=\"Tewitro MPA\" width=\"227\" height=\"151\"\u003e\u003c\/a\u003e\u003c\/p\u003e\r\n\u003cp\u003eWhen the well-plate comes out of the incubator, the TEWL measurement can again be used to monitor when the surplus humidity from the incubator has left the samples and the \u003cspan\u003ereal measurement\u003c\/span\u003e time starts. Depending on the nature of the applied products the barrier of the cultured tissues is more or less intact. When the barrier has been damaged, particles of the cells can be found (microbiologically) in the surrounding medium. However, the \u003cspan\u003edegree of damage or barrier improvement can very accurately be indicated by the monitored TEWL- values\u003c\/span\u003e. The higher they stay, the less intact the barrier.\u003c\/p\u003e\r\n\u003cp\u003e\u003cspan\u003eAdditional Benefits:\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003eThe\u003cspan\u003e micro climate\u003c\/span\u003e in the wells, once they are out of the incubator, is \u003cspan\u003econstantly changing\u003c\/span\u003e. After leaving the incubator, the cultured tissues also dry quickly and shrink soon. Therefore, to get meaningful results, it is important to measure all wells \u003cspan\u003eat the same time\/same conditions and not miss the correct measurement point\u003c\/span\u003e. If you perform single measurements in each well one after the other, the values will never be comparable. For 24 wells such a procedure would take way too long to get reproducible results.\u003c\/li\u003e\r\n\u003cli\u003eExtremely \u003cspan\u003etime- (and manpower-) saving and economic.\u003c\/span\u003e\n\u003c\/li\u003e\r\n\u003cli\u003eThe open chamber TEWL measurement do not inhibit the normal evaporation rate and \u003cspan\u003edoes not cause occlusion.\u003c\/span\u003e\n\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/div\u003e\r\n\u003cp\u003e \u003c\/p\u003e\r\n\u003cp\u003e \u003c\/p\u003e\r\n\u003c\/div\u003e\r\n\u003c\/div\u003e\r\n\u003c\/div\u003e\r\n\u003chr\u003e\r\n\u003cdiv class=\"uk-margin-small uk-margin-remove-top uk-text-center\"\u003e\u003ca class=\"el-content\" title=\"Download brochure\" href=\"https:\/\/www.courage-khazaka.de\/images\/Downloads\/Brochures\/Wissenschaftlich\/Brochure_Tewitro.pdf\" target=\"_blank\"\u003e \u003cspan class=\"uk-text-middle\"\u003eDownload brochure\u003c\/span\u003e\u003c\/a\u003e\u003c\/div\u003e\r\n\u003c\/div\u003e","brand":"Courage + Khazaka electronic GmbH","offers":[{"title":"Default Title","offer_id":45717410119915,"sku":"MED_Tewitro","price":0.0,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0704\/1427\/0699\/files\/Tewitro-TW24_6__97265.1677760718.1000.1200.jpg?v=1723220438","url":"https:\/\/medisa.com.au\/en-nz\/products\/skin-hair-analysis-products-c-k-scientific-products-probes-tewitro-tw-24-transepidermal-waterloss-measurement-in-skin-tissue-models","provider":"Medisa","version":"1.0","type":"link"}