Understanding Prontosan®: The Science Behind Better Wound Healing

Why Wound Cleansing Matters

Before a wound can heal, it must first be clean and balanced. Chronic and acute wounds often develop slough, necrotic tissue, and bacterial biofilm — invisible layers that delay healing and increase infection risk.
Traditional saline cleansing simply rinses the surface, but modern wound management focuses on biofilm disruption and wound bed preparation to create the optimal environment for tissue regeneration.

The Innovation Behind Prontosan®

Developed by B. Braun Medical, Prontosan® is a clinically proven wound cleansing system combining polyhexamethylene biguanide (PHMB) and betaine.
PHMB acts as a broad-spectrum antimicrobial that destroys bacterial membranes while remaining gentle on tissue.
Betaine is a mild surfactant that reduces surface tension, lifting debris, denatured proteins, and lipids from the wound.
Together they remove and prevent biofilm, rebalance the wound environment, and accelerate healing.

Clinical Proof & Global Experience

A large clinical study by Bellingeri et al. (2016) found that Prontosan® significantly improved wound healing and reduced inflammation compared with saline.
Across hospitals in Europe and Australia, case studies have shown rapid recovery in venous leg ulcers, burns, and post-surgical wounds when Prontosan® was used consistently for cleansing and debridement.
Patients reported reduced exudate, faster epithelialisation, and improved comfort during dressing changes.

 How to Use Prontosan®

1. Cleanse – Irrigate the wound thoroughly with Prontosan® Solution to loosen debris and dressing residue.

2. Soak – Apply gauze soaked in solution for 1–10 minutes depending on wound type.

3. Debride – Gently remove slough with the Prontosan® Debridement Pad in circular motions.

4. Dress – Apply Prontosan® Gel or Gel X and cover with a suitable secondary dressing.
   No rinsing is needed before dressing.

The Prontosan® Product Range

Prontosan® Wound Irrigation Solution – cleanses and hydrates wounds of all types.
Prontosan® Wound Gel – ideal for deep or tunnelling wounds requiring moisture balance.
Prontosan® Wound Gel X – thicker formulation for large or exuding wounds, maintaining a moist environment for up to 72 hours.
Prontosan® Debridement Pad – designed for gentle, effective mechanical biofilm removal.

Each product reduces trauma during dressing changes, minimises odour, and supports a cleaner wound bed.

Why Clinicians Trust Prontosan®

• Disrupts and prevents biofilm regrowth

• Non-cytotoxic and safe for repeated use

• Reduces inflammation and odour

• Improves patient comfort

• Clinically validated for chronic wound care

🇦🇺 Available in Australia at Medisa

As an official Australian distributor of B. Braun wound care, Medisa offers the full Prontosan® range with fast nationwide delivery from our Sydney warehouse.
We supply hospitals, clinics, and healthcare professionals with high-quality wound management solutions backed by evidence and expertise.

Recommended Sources

All information and data referenced in this article are derived from official B. Braun publications and peer-reviewed research:

1. Prontosan Made Easy – Wounds International, 2011 (B. Braun Medical AG)

2. Wound Bed Preparation and Cleansing with Prontosan – B. Braun Australia, 2020

3. Bellingeri A et al. (2016). Effect of a Wound Cleansing Solution on Wound Bed Preparation and Inflammation in Chronic Wounds: A Single-Blind RCT. Journal of Wound Care 25(3): 160–168

4. Prontosan Case Studies – B. Braun Medical AG, Center of Excellence for Infection Control

5. How to Change Dressings Hygienically – B. Braun Medical AG, 2018

6. Prontosan Wound Irrigation Solution Instructions for Use – B. Braun Medical AG